function:Acts as a factor that allows the DNA to undergo a single round of replication per cell cycle. Required for the entry in S phase and for cell division.,PTM:Phosphorylated on Ser-108 by ATR in proliferating cells. Ser-108 proliferation is increased by genotoxic agents. Ser-40 is mediated by the CDC7-DBF4 and CDC7-DBF4B complexes, while Ser-53 phosphorylation is only mediated by the CDC7-DBF4 complex.,sequence caution:Translation N-terminally shortened.,similarity:Belongs to the MCM family.,similarity:Contains 1 MCM domain.,subunit:Interacts with DBF4 (By similarity). Interacts with MYST2. May interact with MCM10.,
Nucleus . Chromosome . Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses. .
Bone marrow,Brain,Cervix carcinoma,Colon carcinoma,Epitheli
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