function:Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 BACK (BTB/Kelch associated) domain.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 6 Kelch repeats.,subunit:Interacts with cul3.,
Cytoplasm, cytoskeleton, spindle . Localizes to the spindle midzone and targets CUL3 to this region.
Brain,Hepatoma,Hippocampus,Lung carcinoma,PCR rescued clones,Spleen,
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