TBL1Y Monoclonal Antibody

domain:The F-box-like domain is related to the F-box domain, and apparently displays the same function as component of ubiquitin E3 ligase complexes.,function:F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteosomal degradation of transcription repressor complexes, thereby allowing cofactor exchange.,similarity:Belongs to the WD repeat EBI family.,similarity:Contains 1 F-box-like domain.,similarity:Contains 1 LisH domain.,similarity:Contains 8 WD repeats.,subunit:Probable component of the N-Cor repressor complex and some E3 ubiquitin ligase complex.,tissue specificity:Fetal brain and prostate.,