EIF4EBP3 mouse mAb

function:May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases.,function:Regulates eIF4E activity by preventing its assembly into the eIF4F complex.,PTM:Phosphorylated.,similarity:Belongs to the eIF4E-binding protein family.,similarity:Belongs to the mask family.,similarity:Contains 1 KH domain.,similarity:Contains 25 ANK repeats.,subunit:EIF4EBP3 interacts with EIF4E.,subunit:Interacts with PTPN11. Isoform 2 interacts with VPR.,tissue specificity:Expression is highest in skeletal muscle, heart, kidney, and pancreas, whereas there is very little expression in brain and thymus.,tissue specificity:Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expression in leukemia cells. Isoform 2 is highly expressed in spleen with almost no expression in muscle and brain.,