ASAP2 Polyclonal Antibody

domain:The conserved Arg-464 in the Arf-GAP domain probably becomes part of the active site of bound small GTPases and is necessary for GTP hydrolysis.,function:Activates the small GTPases ARF1, ARF5 and ARF6. Regulates the formation of post-Golgi vesicles and modulates constitutive secretion. Modulates phagocytosis mediated by Fc gamma receptor and ARF6. Modulates PXN recruitment to focal contacts and cell migration.,induction:Up-regulated during monocyte maturation.,PTM:Phosphorylated on tyrosine residues by SRC and PTK2B.,similarity:Contains 1 Arf-GAP domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 2 ANK repeats.,subcellular location:Colocalizes with F-actin and ARF6 in phagocytic cups.,subunit:Binds PXN, ARF1, ARF5, ARF6, PTK2B and SRC.,tissue specificity:Detected in heart, brain, placenta, kidney, monocytes and pancreas.,