disease:A chromosomal aberration involving BCL3 may be a cause of B-cell chronic lymphocytic leukemia (B-CLL). Translocation t(14;19)(q32;q13.1) with immunoglobulin gene regions.,function:Could be a transcriptional activating factor. Functions as a form of I-kappa-B specific for NF-kappa-B p50 subunit inhibiting its translocation to the nucleus.,PTM:Activated by phosphorylation.,similarity:Contains 7 ANK repeats.,subunit:Component of a complex consisting of the NF-kappa-B p52-p52 homodimer and BCL3. Component of a complex consisting of the NF-kappa-B p50-p50 homodimer and BCL3. Interacts with N4BP2 and COPS5.,
Nucleus. Cytoplasm . Cytoplasm, perinuclear region . Ubiquitination via 'Lys-63'-linked ubiquitin chains is required for nuclear accumulation. .
Leukemia,Lung,
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