function:May be involved in coupling the protein kinase C and calmodulin signal transduction systems.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the MARCKS family.,
Cytoplasm, cytoskeleton . Cell membrane ; Lipid-anchor . Associates with the membrane via the insertion of the N-terminal N-myristoyl chain and the partial insertion of the effector domain. Association of the effector domain with membranes may be regulated by Ca(2+)/calmodulin. Colocalizes with F-actin at the leading edge of migrating cells (By similarity). In prostate cancers, shows strong expression at apical and/or basal regions of the cell and also has weak cytoplasmic expression (PubMed:22751924). .
Brain,Epithelium,Muscle,
下载说明书
