ZBT17 Polyclonal Antibody

function:May function as a housekeeping DNA-binding protein that regulates the expression of specific genes. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Also has potent growth arrest activity, probably through inhibition of cell cycle progression. Required for early embryonic development during gastrulation.,similarity:Belongs to the krueppel C2H2-type zinc-finger protein family.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 13 C2H2-type zinc fingers.,subunit:Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A.,