domain:The J domain mediates interaction with HSPA8.,function:Involved in the unfolded protein response (UPR) during ER stress. Co-chaperone of HSPA8/HSC70, it stimulates its ATPase activity. May inhibit both the autophosphorylation of EIF2AK2/PKR and the ability of EIF2AK2 to catalyze phosphorylation of the EIF2A. May inhibit EIF2AK3/PERK activity.,induction:Up-regulated during an endoplasmic reticulum stress via ATF6. Activated in response to infection by influenza virus through the dissociation of DNAJB1. Down-regulated by DNAJB1 and PRKRIR/P52RIPK.,similarity:Contains 1 J domain.,similarity:Contains 9 TPR repeats.,subunit:Interacts with EIF2AK3 (By similarity) and EIF2AK2. Forms a trimeric complex with DNAJB1 and HSPA8. Interacts with PRKRIR/P52RIPK.,tissue specificity:Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.,
Endoplasmic reticulum .
Widely expressed with high level in the pancreas and testis. Also expressed in cell lines with different levels.
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