function:Transcriptional repressor. Binds to the DNA sequence 5'-AACAAT-3'.,similarity:Contains 1 HMG box DNA-binding domain.,
Nucleus . Cytoplasm .
Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation.
下载说明书
