disease:Defects in SAG are a cause of congenital stationary night blindness Oguchi type (CSNBO) [MIM:258100]; also known as Oguchi disease. Congenital stationary night blindness is a non-progressive retinal disorder characterized by impaired night vision. CSNBO is an autosomal recessive form associated with fundus discoloration and abnormally slow dark adaptation.,disease:S-antigen induces autoimmune uveitis.,function:Arrestin is one of the major proteins of the ros (retinal rod outer segments); it binds to photoactivated-phosphorylated rhodopsin, thereby apparently preventing the transducin-mediated activation of phosphodiesterase.,miscellaneous:Arrestin binds calcium.,online information:Retina International's Scientific Newsletter,similarity:Belongs to the arrestin family.,tissue specificity:Retina and pineal gland.,
Cell projection, cilium, photoreceptor outer segment . Membrane ; Peripheral membrane protein . Highly expressed in photoreceptor outer segments in light-exposed retina. Evenly distributed throughout rod photoreceptor cells in dark-adapted retina (By similarity). Predominantly dectected at the proximal region of photoreceptor outer segments, near disk membranes (PubMed:3720866). .
Detected in retina, in the proximal portion of the outer segment of rod photoreceptor cells (at protein level).
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