function:Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis.,PTM:Phosphorylated on tyrosine residues by EGFR.,similarity:Contains 1 EF-hand domain.,similarity:Contains 3 EH domains.,subcellular location:Localized to plasma membrane coated pits.,subunit:Interacts with EPS15, AGFG1/HRB and AGFG2/HRBL. Associates with the clathrin-associated adapter protein complex 2 (AP-2).,
Cell membrane ; Peripheral membrane protein . Nucleus . Membrane, coated pit . Localized to plasma membrane coated pits. .
Brain,Epithelium,Fetal brain,T-cell,Uterus,
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