function:Component of the origin recognition complex (ORC) that binds origins of replication. It has a role in both chromosomal replication and mating type transcriptional silencing. Binds to the ARS consensus sequence (ACS) of origins of replication in an ATP-dependent manner.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the ORC6 family.,subunit:ORC is composed of six subunits. Interacts with DBF4.,
Nucleus.
Cervix,Epithelium,Testis,Whole embryo,
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