catalytic activity:A 3-beta-hydroxy-Delta(5)-steroid + NAD(+) = a 3-oxo-Delta(5)-steroid + NADH.,catalytic activity:A 3-oxo-Delta(5)-steroid = a 3-oxo-Delta(4)-steroid.,function:3-beta-HSD is a bifunctional enzyme, that catalyzes the oxidative conversion of Delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids.,pathway:Lipid metabolism; steroid biosynthesis.,similarity:Belongs to the 3-beta-HSD family.,tissue specificity:Placenta and skin. Predominantly expressed in mammary gland tissue.,
Endoplasmic reticulum membrane; Single-pass membrane protein. Mitochondrion membrane; Single-pass membrane protein.
Placenta and skin (PubMed:1401999). Predominantly expressed in mammary gland tissue.
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