catalytic activity:3-hydroxyanthranilate + O(2) = 2-amino-3-carboxymuconate semialdehyde.,cofactor:Fe(2+) ion.,function:Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.,pathway:Cofactor biosynthesis; NAD(+) biosynthesis; pyridine-2,3-dicarboxylate from L-kynurenine: step 3/3.,similarity:Belongs to the 3-HAO family.,subunit:Monomer.,
Cytoplasm, cytosol .
Brain,Hippocampus,Placenta,
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