8ODP Polyclonal Antibody

catalytic activity:8-oxo-dGTP + H(2)O = 8-oxo-dGMP + diphosphate.,developmental stage:In peripheral blood lymphocytes, expressed at much higher levels in proliferating cells than in resting cells.,function:Antimutagenic. Responsible for preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions.,polymorphism:A polymorphism between Met-1 and Met-19 removes a stop codon before the initiation codon for isoform p22 and gives rise to the production of isoform p26. The allele frequency of isoform p26 is about 20%.,PTM:The N-terminus is blocked.,similarity:Belongs to the Nudix hydrolase family.,tissue specificity:Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.,