catalytic activity:1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate.,function:Converts phosphatidylinositol-3,4,5-triphosphate (PtdIns 3,4,5-P3) to PtdIns-P2. Specific for lipid substrates, inactive towards water soluble inositol phosphates.,miscellaneous:Active in the presence of octyl-glucoside or Triton X-100, but completely inhibited by CTAB.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Several sequencing problems.,similarity:Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type IV family.,subcellular location:Peripheral membrane protein associated with Golgi stacks.,tissue specificity:Detected in brain, heart, pancreas, testis and spleen.,
Cytoplasm, cytoskeleton, cilium axoneme . Golgi apparatus, Golgi stack membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, ruffle . Cytoplasm . Nucleus . Peripheral membrane protein associated with Golgi stacks. .
Detected in brain, heart, pancreas, testis and spleen.
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