cofactor:Binds 1 zinc ion per subunit.,disease:Defects in ADAM33 may be a cause of susceptibility to asthma.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins.,
Membrane; Single-pass type I membrane protein.
Expressed in all tissues, except liver, with high expression in placenta, lung, spleen and veins.
下载说明书
