caution:Has sometimes been referred to as ADAM-12.,cofactor:Binds 1 zinc ion per subunit.,function:Probable zinc protease. May mediate cell-cell or cell-matrix interactions. Isoform 2 displays alpha-secretase activity for APP.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 EGF-like domain.,similarity:Contains 1 peptidase M12B domain.,tissue specificity:Widely expressed. Expressed in chondrocytes. Highest expression of isoform 2 found in liver and heart.,
[Isoform 1]: Cell membrane ; Single-pass type I membrane protein .; [Isoform 2]: Secreted .
Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart.
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