domain:The spacer domain and the TSP type-1 domains are important for a tight interaction with the extracellular matrix.,function:Has a aminoprocollagen type I activity processing activity in the absence of ADAMTS2. Seems to be synthesized as a latent enzyme that requires activation to display aminoprocollagen peptidase activity.,PTM:The precursor is cleaved by a furin endopeptidase.,similarity:Contains 1 disintegrin domain.,similarity:Contains 1 peptidase M12B domain.,similarity:Contains 1 PLAC domain.,similarity:Contains 4 TSP type-1 domains.,tissue specificity:Expressed in retina and at low levels in brain, lung and placenta. High expression in fetal tissues.,
Secreted, extracellular space, extracellular matrix .
Expressed in retina and at low levels in brain, lung and placenta (PubMed:11779638). High expression in fetal tissues (PubMed:11867212).
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