function:Component of the basal lamina that causes the aggregation of acetylcholine receptors and acetylcholine-esterase on the surface of muscle fibers of the neuromuscular junction.,PTM:Contains heparan sulfate chains as well as N-linked and O-linked oligosaccharides.,similarity:Contains 1 NtA (N-terminal agrin) domain.,similarity:Contains 1 SEA domain.,similarity:Contains 2 laminin EGF-like domains.,similarity:Contains 3 laminin G-like domains.,similarity:Contains 4 EGF-like domains.,similarity:Contains 9 Kazal-like domains.,subcellular location:Synaptic basal lamina at the neuromuscular junction.,subunit:Binds to laminin.,
[Isoform 1]: Secreted, extracellular space, extracellular matrix . Synaptic basal lamina at the neuromuscular junction. .; [Isoform 2]: Cell junction, synapse . Cell membrane ; Single-pass type II membrane protein .
Expressed in basement membranes of lung and kidney. Muscle- and neuron-specific isoforms are found. Isoforms (y+) with the 4 AA insert and (z+8) isoforms with the 8 AA insert are all neuron-specific. Isoforms (z+11) are found in both neuronal and non-neuronal tissues.
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