disease:Defects in PDS5B may be the cause of some cancers including esophageal cancer.,function:Plays a role in androgen-induced proliferative arrest in prostate cells. Required for maintenance of sister chromatid cohesion during mitosis.,induction:By the synthetic androgen R1881 in prostate carcinoma cells undergoing proliferative arrest. Maximum levels occur 18-20 hours after androgen exposure.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the PDS5 family.,similarity:Contains 1 HEAT repeat.,similarity:Contains 3 A.T hook DNA-binding domains.,subunit:Interacts with the cohesin complex.,tissue specificity:Widely expressed.,
Nucleus .
Widely expressed.
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