domain:The angiostatin binding domain (871-1005) allows the binding to angiostatin.,domain:The coiled coil domain interacts directly with the BAR domain of ARHGAP17.,function:Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.,miscellaneous:'Motus' means motility in Latin.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the angiomotin family.,subcellular location:Localized on the cell surface. May act as a transmembrane protein.,subunit:Component of a complex whose core is composed of ARHGAP17, AMOT, MPP5/PALS1, INADL/PATJ and PARD3/PAR3. Interacts with MAGI1. Isoform 1 interacts with angiostatin.,tissue specificity:Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.,
Cell junction, tight junction . Localized on the cell surface. May act as a transmembrane protein.
Expressed in placenta and skeletal muscle. Found in the endothelial cells of capillaries as well as larger vessels of the placenta.
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