developmental stage:Expressed in fetal liver, kidney and brain.,function:May play a role in the processing of autolysosomes.,PTM:N-glycosylated.,similarity:Belongs to the ABC transporter family.,similarity:Belongs to the ABC transporter family. ABCA subfamily.,similarity:Contains 2 ABC transporter domains.,tissue specificity:Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta.,
Golgi apparatus membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Cell membrane . Localized at cell membrane under high cholesterol levels. .
Ubiquitously expressed. Highly expressed in testis, skeletal muscle, kidney, liver and placenta. Expressed in both the epithelial and mesenchymal compartments, present within the outer root sheath (ORS) of the hair follicle as well as dermal sheath (PubMed:24831815). Expressed in multiple regions of the brain, including the hippocampus, superior frontal and inferior temporal cortices (PubMed:25125465). Strongly expressed in neurons and moderately in microglia, with only weak expression in astrocytes and oligodendrocytes (PubMed:25125465).
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