function:May be required for replication-independent chromatin assembly. May serve as a negative regulator of T-cell receptor (TCR) signaling via inhibition of calcineurin. Inhibition of activated calcineurin is dependent on both PKC and calcium signals.,PTM:Activated through PKC-mediated hyperphosphorylation. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 6 TPR repeats.,subunit:Component of a complex that includes at least ASF1A, CABIN1, HIRA, histone H3.3 and UBN1. Interacts with calcineurin. Interacts with MEF2B.,tissue specificity:Widely expressed in different tissues.,
Nucleus .
Widely expressed in different tissues.
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