catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).,function:Has a higher affinity for cGMP than for cAMP.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,subunit:Homodimer.,tissue specificity:Several tissues, including brain, kidney, testes and heart.,
nucleus,cytosol,neuronal cell body,
Several tissues, including brain, kidney, testes and heart.
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