catalytic activity:Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.,enzyme regulation:Type I PDE are activated by the binding of calmodulin in the presence of Ca(2+).,function:Has a preference for cGMP as a substrate.,similarity:Belongs to the cyclic nucleotide phosphodiesterase family.,subunit:Homodimer.,
Cytoplasm, cytosol .
Brain,Human uterus,Testis,
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