disease:Defects in CAMTA1 are detected in patients with oligodendroglioma and astrocytoma.,function:Transcriptional activator. May act as a tumor suppressor.,induction:Detected at low levels at interphase and in resting cells. Up-regulated during S-phase and mitosis. Levels decrease at the end of mitosis.,similarity:Belongs to the CAMTA family.,similarity:Contains 1 CG-1 DNA-binding domain.,similarity:Contains 1 IPT/TIG domain.,similarity:Contains 3 ANK repeats.,similarity:Contains 3 IQ domains.,subunit:May interact with calmodulin .,tissue specificity:Detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen, heart and kidney. Detected in neuroblastic-type cultured neuroblastoma cells.,
Nucleus . Cytoplasm .
Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells. Expressed in heart and kidney.
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