CTSR1 Polyclonal Antibody

developmental stage:Expressed meiotically and poszt-meiotically.,function:Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization.,induction:Down-regulated in patients lacking sperm motility.,similarity:Belongs to the cation channel sperm-associated family.,subunit:Heterotetramer; possibly composed of CATSPER1, CATSPER2, CATSPER3 and CATSPER4 (Potential). Component of a complex, at least composed of CATSPER1, HSPA1B and CATSPERB. Interacts with CATSPER3 and CATSPER4 (By similarity). Interacts with Ca(v)3.3/CACNA1I, leading to suppress T-type calcium channel activity.,tissue specificity:Testis-specific. Specifically present in the principal piece of sperm tail (at protein level).,