enzyme regulation:GAP activity stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid.,function:GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6).,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 Arf-GAP domain.,similarity:Contains 1 BAR domain.,similarity:Contains 1 PH domain.,similarity:Contains 3 ANK repeats.,tissue specificity:Widely expressed. Highest level in lung.,
Endosome membrane ; Peripheral membrane protein .
Widely expressed. Highest level in lung.
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