developmental stage:Highly expressed in fetal liver.,function:Binds to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter.,induction:Induced by serum in low-passage fibroblasts.,similarity:Contains 1 dDENN domain.,similarity:Contains 1 DENN domain.,similarity:Contains 1 uDENN domain.,similarity:Contains 2 PPR (pentatricopeptide) repeats.,tissue specificity:Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner.,
Nucleus .
Expressed ubiquitously. Highest expression in bone marrow, medium in peripheral blood lymphocytes and lowest in spleen. In brain, breast, and prostate, higher expression was seen in normal cells than in tumor cells. Expression is regulated in a growth- and cell cycle-dependent manner.
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