domain:The DHR-2 domain mediates GEF activity.,function:Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 'Ser-15' phosphorylation during axon formation and consequently for neuronal polarization.,similarity:Belongs to the DOCK family.,similarity:Contains 1 DHR-1 (CZH-1) domain.,similarity:Contains 1 DHR-2 (CZH-2) domain.,subcellular location:Enriched in the developing axons of hippocampal neurons.,subunit:Interacts with TSC1. Interacts with nucleotide-free RAC1 and RAC3.,tissue specificity:Widely expressed.,
Cell projection, axon . Enriched in the developing axons of hippocampal neurons.
Widely expressed.
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