function:Has NAD-dependent 17-beta-hydroxysteroid dehydrogenase activity. Converts oestradiol to oestrone. The physiological substrate is not known. Acts on oestradiol and 5-androstene-3-beta,17-beta-diol (in vitro).,similarity:Belongs to the short-chain dehydrogenases/reductases (SDR) family.,subunit:Homotetramer.,tissue specificity:Highly expressed in brain, placenta, liver and kidney.,
Cytoplasm .
Highly expressed in brain, placenta, liver and kidney.