catalytic activity:Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.,enzyme regulation:Inhibited by niacin.,function:Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation.,pathway:Glycerolipid metabolism; triacylglycerol biosynthesis.,similarity:Belongs to the diacylglycerol acyltransferase family.,tissue specificity:Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammaray gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.,
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Lipid droplet . Cytoplasm, perinuclear region .
Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.
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