developmental stage:Expressed in fetal and pediatric kidney cells.,function:E3 ubiquitin-protein ligase that may function in cellular proteins degradation.,induction:Down-regulated in sporadic Wilms tumor.,pathway:Protein modification; protein ubiquitination.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 6 ANK repeats.,subcellular location:A significant portion localizes to the endoplasmic reticulum.,subunit:Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.,tissue specificity:Expressed in multiple tissues including heart, brain and kidney.,
Golgi apparatus, Golgi stack membrane. Cytoplasm. Endoplasmic reticulum. A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
Expressed in multiple tissues including heart, brain and kidney.
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