function:May act as an E3 ubiquitin-protein ligase, or as part of the E3 complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, such as UBE2E1, and then transfers it to substrates, such as SLC22A18. May play a role in growth regulation involved in G1/S transition.,pathway:Protein modification; protein ubiquitination.,PTM:Auto-ubiquitinated in vitro in the presence of UBE2D1 and UBE2E1.,similarity:Contains 1 PA (protease associated) domain.,similarity:Contains 1 RING-type zinc finger.,subcellular location:Targeted to cytoplasmic membranes.,subunit:Interacts with SLC22A18.,tissue specificity:Strongly expressed in the kidney and liver (at protein level).,
Endomembrane system ; Single-pass membrane protein . Targeted to cytoplasmic membranes.
Strongly expressed in the kidney and liver (at protein level).
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