MCF2L Polyclonal Antibody

domain:The CRAL-TRIO domain is involved in interaction with inositol phospholipids.,domain:The DH domain is involved in interaction with CCPG1.,function:Guanine nucleotide exchange factor that potentially links pathways that signal through RAC1, RHOA and CDC42. Catalyzes guanine nucleotide exchange on RHOA and CDC42 and interacts specifically with the GTP-bound form of RAC1, suggesting that it functions as an effector of RAC1. May also participate in axonal transport in the brain. Becomes activated and highly tumorigenic by truncation of the N-terminus (By similarity). Isoform 5 activates CDC42.,similarity:Belongs to the MCF2 family.,similarity:Contains 1 CRAL-TRIO domain.,similarity:Contains 1 DH (DBL-homology) domain.,similarity:Contains 1 PH domain.,similarity:Contains 1 SH3 domain.,similarity:Contains 1 spectrin repeat.,subunit:Interacts with CCPG1, which results in specific inhibition of its exchange activity toward RHOA (By similarity). Interacts with an array of inositol phospholipids such as phosphatidylinositol 3-phosphate (PI3P), phosphatidylinositol 4-phosphate (PI4P) and phosphatidylinositol 5-phosphate (PI5P).,