alternative products:Additional isoforms seem to exist,caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,function:Associates specifically with huntingtin. This binding is enhanced by an expanded polyglutamine repeat.,similarity:Contains 1 HAP1 N-terminal domain.,tissue specificity:Predominantly expressed in brain. Selectively expressed in neurons.,
Cytoplasm . Cell projection, axon . Cell junction, synapse, presynapse . Cytoplasm, cytoskeleton . Cell projection, dendritic spine . Cell projection, dendrite . Lysosome . Endoplasmic reticulum . Mitochondrion . Nucleus . Cytoplasmic vesicle, autophagosome . Early endosome . Cell projection, growth cone . Cell projection, neuron projection . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Localizes to large nonmembrane-bound cytoplasmic bodies found in various types of neurons, called stigmoid bodies (STBs). Localization to neuronal processes and neurite tips is decreased by YWHAZ. In the nucleus localizes to nuclear rods. .
Predominantly expressed in brain. Selectively expressed in neurons.
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