disease:A chromosomal aberration involving LHX4 may be a cause of acute lymphoblastic leukemia. Translocation t(1;14)(q25;q32) with IGHG1.,disease:Defects in LHX4 are the cause of Machinis syndrome [MIM:606606]. It is characterized by short stature, pituitary and cerebellar defects, and small sella turcica.,function:May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 LIM zinc-binding domain.,similarity:Contains 2 LIM zinc-binding domains.,
Nucleus .
Muscle,Placenta,
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