MDFIC Polyclonal Antibody

domain:The cysteine-rich C-terminus is involved in its granular distribution in the cytoplasm.,function:Modulates the expression from both cellular and viral promoters. Down-regulates Tat-dependent transcription of the human immunodeficiency virus type 1 (HIV-1) LTR by interacting with HIV-1 Tat and Rev and impairing their nuclear import, probably by rendering the NLS domains inaccessible to importin-beta. Also stimulates activation of human T-cell leukemia virus type I (HTLV-I) LTR. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways.,similarity:Belongs to the MDFI family.,subcellular location:Isoform 1 localizes to the nucleolus and also shows a granular distribution in the cytoplasm. Isoform 2 is predominantly distributed throughout the cytoplasm, with only weak expression in the nucleus.,subunit:The C-terminus interacts with HIV-1 Tat and Rev, AXIN1, the histidine-rich region of CCNT1/CYCLIN T and weakly with LEF1.,tissue specificity:Expressed in lymphoid organs (spleen, thymus, peripheral blood leukocytes) as well as prostate, uterus and small intestine.,