domain:The U-box-like region is a truncated U-box domain. It is unknown whether it is functional or not.,function:Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the NOSIP family.,subcellular location:Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle.,subunit:Interacts with NOS1 and NOS3.,tissue specificity:Expressed in heart, brain and lung. Present in endothelial cells (at protein level).,
Cytoplasm . Nucleus . Translocates from nucleus to cytoplasm in the G2 phase of the cell cycle (PubMed:16135813).
Expressed in heart, brain and lung. Present in endothelial cells (at protein level).
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