disease:Defects in NR0B2 may be associated with early-onset obesity [MIM:601665].,function:Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts.,similarity:Belongs to the nuclear hormone receptor family. NR0 subfamily.,subunit:Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A.,tissue specificity:Liver. Low levels of expression were detected in heart and pancreas.,
Nucleus . Cytoplasm . Colocalizes with NEUROD1 in the nucleus.
Liver. Low levels of expression were detected in heart and pancreas.
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