PACS1 Polyclonal Antibody

function:Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the PACS family.,subcellular location:Localizes in the perinuclear region, probably the TGN.,subunit:Interacts with HIV-1 Nef, AP-1 and AP-3 but not with AP-2. Forms a ternary complex with furin and AP-1. Combines with Nef to usurp the ARF6 endocytic pathway by a PI3K-dependent process to remove cell surface MHC-I molecules.,