domain:The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.,function:Potassium channel subunit. Modulates channel activity and reduces the ion flow.,similarity:Belongs to the potassium channel family. S subfamily.,subcellular location:May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1.,subunit:Heteromultimer with KCNB1 and with KCNB2. Does not form homomultimers. Might also bind to other channel proteins.,tissue specificity:Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung.,
Cell membrane ; Multi-pass membrane protein . May not reach the plasma membrane but remain in an intracellular compartment in the absence of KCNB1 (PubMed:10484328). .
Detected in whole normal term placental and placental chorionic plate arteries and veins. Detected in syncytiotrophoblast and in blood vessel endothelium within intermediate villi and chorionic plate (at protein level) (PubMed:22943705). Detected in most tissues, but not in peripheral blood lymphocytes. The highest levels of expression are in lung (PubMed:10484328).
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