PR40A Polyclonal Antibody

domain:The WW domains are essential for localization to nuclear speckles.,function:Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). May be involved in pre-mRNA splicing.,sequence caution:Contaminating sequence. Potential poly-A sequence starting in position 409.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the PRPF40 family.,similarity:Contains 2 WW domains.,similarity:Contains 5 FF domains.,subunit:Interacts with the N-terminus of HTT. Interacts with the phosphorylated carboxyterminal domain of POLR2A. Interacts with SF1, SRPK1 CARD8, ATBF1 and MECP2 (By similarity). Interacts through the WW domains with formin proline-rich regions and with WASL/N-WASP.,tissue specificity:Widely expressed.,