catalytic activity:ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.,function:Catalyzes the covalent attachment of ubiquitin to other proteins.,pathway:Protein modification; protein ubiquitination.,similarity:Belongs to the ubiquitin-conjugating enzyme family.,subunit:Homodimer.,
Nucleus . In the nucleus, colocalizes with FANCL. .
Widely expressed, with highest expression in brain, liver, pancreas and heart.