function:Acts as an A-kinase anchoring protein by binding to the type II regulatory subunit of protein kinase A and anchoring it to the mitochondrion. Also involved in synchronization of mitochondrial fission.,similarity:Belongs to the small GTPase superfamily. Rab family.,tissue specificity:Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.,
Mitochondrion . Mitochondrion outer membrane ; Lipid-anchor . Cytoplasmic vesicle, phagosome . Cytoplasmic vesicle, phagosome membrane ; Lipid-anchor ; Cytoplasmic side . Melanosome . Melanosome membrane . Recruited to phagosomes containing S.aureus or M.tuberculosis (PubMed:21255211). The BLOC-3 complex, a heterodimer of HPS1 and HPS4 promotes its membrane localization (PubMed:23084991). .
Widely expressed with high levels in heart, liver, kidney, bone marrow, testis, colon and fetal lung.
下载说明书
