alternative products:Additional isoforms seem to exist,catalytic activity:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.,function:Interacts with LAR-interacting protein LIP.1.,PTM:A cleavage occurs, separating the extracellular domain from the transmembrane segment. This process called 'ectodomain shedding' is thought to be involved in receptor desensitization, signal transduction and/or membrane localization.,similarity:Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily.,similarity:Contains 2 tyrosine-protein phosphatase domains.,similarity:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.,similarity:Contains 8 fibronectin type-III domains.,subunit:Interacts with PPFIA1, PPFIA2 and PPFIA3.,tissue specificity:Detected in all tissues tested except for placenta and liver.,
Cell membrane ; Single-pass type I membrane protein . Cell projection, axon . Perikaryon . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane . Cell junction, synapse, synaptosome . Cell junction, synapse, postsynaptic density . Cell projection, neuron projection . Cell projection, growth cone . Is rapidly internalized when dendritic cells are stimulated with the TLR9 ligand cytidine-phosphate-guanosine (CpG) (PubMed:26231120). Detected in a punctate pattern along neurites and axon growth cones (By similarity). .
Detected in peripheral blood plasmacytoid dendritic cells (at protein level) (PubMed:26231120). Detected in all tissues tested except for placenta and liver (PubMed:8524829, PubMed:8992885). Detected in peripheral blood plasmacytoid dendritic cells (PubMed:26231120).
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