function:GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state. Acts as a GTPase activitor in vitro for CDC42 and RAC1.,sequence caution:Translation N-terminally extended.,similarity:Contains 1 BAR domain.,similarity:Contains 1 Rho-GAP domain.,tissue specificity:Highly expressed in brain. Expressed at weak level in other tissues.,
Cell projection, dendritic spine . Recycling endosome . Cell junction, synapse, presynapse . Cell projection, dendrite . In CA1 hippocampal synapses, detected at both presynaptic and postsynaptic sites (By similarity). Located in convoluted dendritic plasma membrane sections enriched in polymerized actin and myosin (patches) along dendrites where often emerge filopodia (By similarity). .
Highly expressed in brain. Expressed at weak level in other tissues.
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