RHPN2 Polyclonal Antibody

function:Binds specifically to GTP-Rho. May function in a Rho pathway to limit stress fiber formation and/or increase the turnover of F-actin structures in the absence of high levels of RhoA activity.,induction:By thyrotropin (TSH). Regulated by the cAMP pathway.,similarity:Belongs to the RHPN family.,similarity:Contains 1 BRO1 domain.,similarity:Contains 1 PDZ (DHR) domain.,similarity:Contains 1 REM (Hr1) repeat.,subunit:Interacts with GTP-bound RhoA and RhoB. Interacts with both GTP- and GDP-bound RhoA. According to PubMed:12473120, it does not interact with RhoA. Interacts with KRT18.,tissue specificity:Widely expressed. Highly expressed in prostate, trachea, stomach, colon, thyroid and pancreas. Expressed at lower level in brain, spinal cord, kidney, placenta and liver.,